Fenoprofen

Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID). Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the US as Nalfon.

Fenoprofen
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa681026
Pregnancy
category
  • US: D (Evidence of risk)
  • C
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
MetabolismMajor urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
Elimination half-life3 hours
ExcretionRenal (~90%)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.045.231
Chemical and physical data
FormulaC15H14O3
Molar mass242.274 g·mol−1
3D model (JSmol)
  (verify)

As of 2015 the cost for a typical month of medication in the United States is 50 to US$100.[1]

Pharmacology

Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase (COX-2 inhibitor) activity and prostaglandin synthesis.

Contraindications

History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Drug interactions
  • Aminoglycosides (e.g. gentamicin): Plasma aminoglycoside levels may be elevated.
  • Angiotensin-converting enzyme (ACE) inhibitors: Antihypertensive effect of ACE inhibitors may be diminished.
  • Anticoagulants: Coadministration may prolong prothrombin time.
  • Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended.
  • Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides.
  • Hydantoins, sulfonamides, sulfonylureas: Fenoprofen may displace these drugs from their binding site.
  • Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity.
  • Methotrexate: May increase methotrexate levels.
  • Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn.
  • SSRIs (e.g. fluoxetine, citalopram): The risk of GI effects may be increased.

Laboratory test interactions

False elevation in free and total serum T 3 as measured by Amerlex-M kit.

Brand names
  • UK - Fenopron (Typharm Limited)

References
  1. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 8X. ISBN 9781284057560.
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